In this test method, only the nose of the animal is exposed to the test substance. The animal is contained within a specially made holder, this holder is then set into the exposing chamber, and test substances controlled by regulatory concentrations are supplied and exposed. The feature of SIBATA chambers is that the air volume in the inhalation chamber is kept as low as possible, so that the test substance is exposed efficiently; therefore it is well suited for inhalation tests that use expensive samples. this method is applied to inhalation tests when the substance is easily influenced by oral or skin contact.
Nose only exposure inhalation system
Our Nose Only Exposure inhalation device has been developed for inhalation toxicity tests of environmental contaminants, kinetic tests and pharmacological tests that are indispensable for the development of pharmaceutical products.
For tests using precious pharmaceutical products or when the toxicity of the substance is high, it is favorable to keep consumption of the exposed substance to a minimum. Consumption has gone down to only a fraction of what had been used in the past. The exhaled substance will not influence the test substance by utilizing a separate air supply(substance intake) tank and exhaust tank.
※ Conserves consumption of administered substance
※ Constructed with separate air supply and exhaust system so that the exposed substance (including air) does not contaminate the supply to other animals.
※ The holder is made of clear acrylic, so that the animals can be observed from the outside.(utility design)
※ Exposure chamber is double tubed with no leakage outside the holder.
※ Exposure chamber turns, making it easier to put the holder in place and take out.
※ Both exposure chamber and holder have sealed construction and is safe for inhalation studies of highly toxic substances.
※ Best for testing Nano Particles.
Exposure method
Separate air supply and exhaust, Nose only exposure inhalation method
Animal
Rat, mice 10,20,30
Guinea pigs 12,16,20
Models used for both also available
Inhalation substance
(concentration)
Aerosol(～1g/m3)
Mist (～1g/m3)
Gas (～approx.2000ppm)
Ventilating flow volume
5～30L/min
Air supply
High-efficiency filter(W)
Exhaust treatment
Bubbler，high-efficiency filter, activated carbon
Base
Outside dimensions 1350(W)×750(D)×1900(H)mm
Material main of body finish
SS41 painted
Draft chamber
clear vinyl chloride
Power
AC100v 20A or 3phase 200V 15A
